Custom OTC Medicine Boxes

All custom OTC Medicine Boxes you need for your products

FREE Shipping All Across the USA No minimums, no hidden freight fees — to all 50 states.

FREE 3D Design Tool Build & preview your box online before you order.

FREE Design Support Our US team perfects your artwork & 3D mockup.

Custom OTC medicine boxes for US over-the-counter pharmaceutical brands. We print folding cartons from 100 units with fully-laid-out Drug Facts panels — sized to fit the minimum FDA readability requirement, printed in the exact typographic hierarchy the FDA specifies.

For US OTC drug brands, dietary-adjacent wellness founders (pain relief, allergy, sleep, digestive), and private-label OTC contract manufacturers.

About Custom OTC Medicine Boxes

OTC medicine boxes built to the Drug Facts spec

Over-the-counter medicine packaging in the US is governed by the FDA Drug Facts panel — a required, standardized label section that must appear on nearly every OTC drug carton. The typographic hierarchy is prescriptive (Helvetica, minimum 6pt body, bold subheads for Active Ingredients / Uses / Warnings / Directions / Other Information / Inactive Ingredients), and the panel has minimum dimensions that constrain how small your carton can go. We lay out the panel to spec as part of free dieline design.

Sizing, tamper-evidence, and structural specs

Standard reverse tuck-end in 18-22pt SBS is the workhorse. Minimum carton size is driven by Drug Facts readability — typically ~45×90mm printable footprint for a compact tablet SKU. Larger SKUs (liquid dose cups, ointment tubes, blister packs) fit larger cartons. For tamper-evidence, a printed tuck-flap glue-seal or a shrink band around the closure is the standard signal. Rigid two-piece is uncommon in OTC and skipped unless a specific launch positioning justifies it.

Custom OTC medicine boxes shipping across the United States

Ships free to every US state — New York, California, Texas, Florida, Illinois, Pennsylvania, Ohio, Georgia, North Carolina, Michigan see 3-5 day Ground transit. Buyers searching "custom OTC medicine boxes near me" or "Drug Facts carton printer in [state]" reach CBP as a US-based packaging supplier with 7-10 business day production. Direct drop-ship to a contract-manufacturing fulfillment center is standard.

MOQ, pricing, and how to order

MOQ 100. A standard 30-tablet OTC carton in 18pt SBS with a full Drug Facts panel + 4-color print: ~$1.35 at 250, ~$1.05 at 500, ~$0.82 at 1,000. Larger 6-8 oz syrup cartons run 30-50% more for the board weight. Send us your active ingredient, dose, and approved artwork. Related: medicine boxes hub, supplement boxes, capsule boxes, softgel boxes.

Regulatory notes

OTC drugs are FDA-regulated; the box design (Drug Facts panel typography, NDC placement, warnings) is your regulatory affairs team's approval to make. We print the artwork you supply and give you a free layout review to confirm the panel meets the FDA typographic spec (font, size, line spacing, bold hierarchy) before print.

Why US brands choose us for custom otc medicine boxes

Custom Box Printing manufactures custom otc medicine boxes from our US production facility, with free standard shipping anywhere in the contiguous United States and a 7–10 business day turnaround. We've printed custom otc medicine boxes for solo founders launching their first product line, growing direct-to-consumer brands placing 5,000-unit runs, and established retail brands with 50,000+ unit production schedules — and we treat all three the same: no minimums, free design support, no setup or die-plate charges, and a 3D digital mockup before anything goes to press.

Every custom otc medicine boxes order includes free in-house dieline and artwork support — our US-based designers will polish your existing files, or build a custom dieline from scratch to fit your exact product dimensions. We send you a 3D mockup to confirm look and proportions before production. For color-critical work, request a physical sample free — let’s talk about a customized sample so you can confirm the look before a full run.

Materials, print, and finish options

OTC packaging is functional-first: the Drug Facts panel has to be printed in a specific typographic hierarchy (Helvetica, minimum type sizes, bold subheads, ordered sections) or the box gets flagged at retail and can trigger an FDA warning letter. Standard body is 18-22pt SBS — bright white for panel legibility, stiff enough to hold shape through the retail supply chain. The minimum carton footprint is driven by the Drug Facts panel itself: typically ~45mm × 90mm printable area for a compact tablet SKU. Add tamper-evident sealing on the tuck flap where required.

Available finishes include:

Lamination: Gloss, matte, soft-touch, or velvet finish for a premium hand-feel.
Foil stamping: Gold, silver, copper, or custom foil colors for high-visibility brand marks.
Embossing & debossing: Tactile raised or recessed surface effects on logo or key artwork.
Spot UV: Selective gloss coating that creates contrast against matte areas.
Eco-friendly options: Recycled kraft, FSC-certified stocks, water-based inks, recyclable rigid constructions.
Compliance: FDA food-safe inks; certified child-resistant constructions for CBD/cannabis where required.

If you're not sure which combination will work best for your custom otc medicine boxes, mention it in your quote request — our team will recommend the right material, print spec, and finish based on your product, budget, and brand positioning.

How to order your custom otc medicine boxes

Request a quote — use the "Get Free Quote" button on this page, or call (855) 792-3890 (toll free). Tell us your box style, dimensions, quantity, material preferences, and any deadline.
We respond within 1 business day with pricing, lead times, and material recommendations. No pressure, no commitment.
Free design + 3D mockup — we build your dieline (or polish your existing artwork) and send you a 3D digital mockup to approve.
Optional physical sample — request a free custom sample to hold the real box in hand — let’s talk it through.
Production & free US shipping — once you approve, we print and ship in 7–10 business days, free anywhere in the United States.

Custom OTC Medicine Boxes — Frequently Asked Questions

We have no minimum order quantity for custom otc medicine boxes. You can order as few as 100 units for a brand test, or scale to 50,000+ for a full retail run — pricing per unit improves with volume.

Yes — standard shipping is free anywhere in the contiguous United States on every order. Rush production (3–5 business days) and expedited shipping are available on request for an additional fee.

Standard production turnaround is 7–10 business days from artwork approval. We confirm your dieline, send a 3D digital mockup, and start production once you approve. Rush orders typically ship in 3–5 business days.

Yes. Physical samples are free — just ask and we’ll sort out a customized sample for your box, no obligation. We also send a free 3D digital mockup with every quote.

Yes — we stock recycled kraft, FSC-certified paperboards, water-based and soy-based inks, and recyclable corrugated and rigid stocks. Mention "eco" in your quote request and we'll recommend the best material for your product.

Full-color CMYK offset printing with Pantone spot matching is standard. Premium finishes include gloss / matte lamination, soft-touch, spot UV, embossing, debossing, and gold or silver foil stamping. Custom die-cut shapes are available on request.

Yes — CBP prints Drug-Facts-panel-compliant OTC cartons and ships free to every US state including New York, California, Texas, Florida, and Illinois. Standard production 7-10 business days from approved artwork.

Standard production 7-10 business days + 3-5 days Ground to Texas or Florida. Rush 3-5 day production is available; we can drop-ship direct to your contract manufacturer or fulfillment center.

We give you a free layout review to confirm your Drug Facts panel meets the FDA typographic spec (Helvetica, size hierarchy, bold subheads). If you need panel design from scratch, we can quote that as an add-on — most brands supply the panel already reviewed by their regulatory team.

MOQ 100. Standard 30-tablet OTC carton in 18pt SBS with Drug Facts + 4-color print: ~$1.35 at 250, ~$1.05 at 500, ~$0.82 at 1,000. Add ~$0.08/unit for a printed tamper-evident glue-seal on the tuck flap.

Yes — printed tuck-flap glue-seal (paper-to-paper, breaks visibly on open) or a shrink band around the closure. Glue-seal is included at cost; shrink bands add $0.05-$0.12 per unit depending on band spec.